What is the purpose of this study?
This study aims to compare several different treatments that may be useful for patients with COVID-19. These treatments have been recommended for testing by the expert panel that advises the Chief Medical Officer in England. Some are tablets and some are injections. Although these treatments show promise, nobody knows if any of them will turn out to be more effective in helping patients recover than the usual standard of care at your hospital (which all patients will receive).
The treatments, which may be given in addition to the usual care at your hospital, are: Lopinavir-Ritonavir (commonly used to treat HIV); corticosteroids (a type of steroid, which are used in a range of conditions typically to reduce inflammation [the precise type differing in pregnant women and other participants, but all in common use]); hydroxychloroquine (a treatment for malaria); or azithromycin (a commonly-used antibiotic).
You may also receive convalescent plasma (the liquid part of blood which carries blood cells around the body) which has been collected from individuals who have recovered from COVID-19 infection and contains antibodies to the virus that may help you fight the virus. For patients whose condition is more severe, tocilizumab (a treatment for rheumatoid arthritis) is also an option. At present, we don’t know whether any of these are effective in treating COVID-19. However, the side-effects are well-known from other uses and your doctor will be able to monitor you appropriately.