What is the purpose of this study?
This study aims to compare several different treatments that may be useful for patients with COVID-19. These treatments have been recommended for testing by the expert panel that advises the Chief Medical Officer in England. Some are tablets and some are injections. Although these treatments show promise, nobody knows if any of them will turn out to be more effective in helping patients recover than the usual standard of care at your hospital (which all patients will receive).
The treatment, which may be given in addition to the usual care at your hospital, are: Colchicine (an anti-inflammatory), baricitinib (a treatment for rheumatoid arthritis) and/or aspirin. You may also receive a mixture of two antibodies which have been designed to neutralise the coronavirus (called monoclonal antibodies, or Mab for short). At present, we don’t know whether any of these are effective in treating COVID-19. However, the side-effects are well-known from other uses (except for the Mab which is a new treatment) and your doctor will be able to monitor you appropriately. At some sites we may also assess other treatments; further details are on the last page and your study team can tell you if this is relevant for you or not.