Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

  • Dexamethasone may also disturb sleep and increase the risk of infections. In people with diabetes it can raise blood sugar.
  • Oseltamivir may cause headache, tummy upset and allergic reactions.
  • Baloxavir rarely causes allergic reactions, but has no other known side effects.
  • Sotrovimab is given by intravenous infusion and may cause allergic reactions during the infusion, but severe reactions have been rare.

There is also the unlikely possibility of a severe reaction to any study drug. Please ask your hospital doctor if you would like more information. Once you have been included in the study, you and your doctors will know which treatment the computer has allocated for you. Your doctors will be aware of whether there are any particular side effects that they should look out for.

Women who are pregnant may be included, however, the effect of some of the treatments on unborn babies is uncertain. Dexamethasone and oseltamivir have previously been used in pregnancy for other medical conditions without safety concerns being raised. Baloxavir and sotrovimab have not been used in pregnant women before but are considered to have an acceptably low level of risk to use in pregnant women in this trial by a national expert panel; your medical team will discuss with you whether you would be willing to receive them.